Three people have died following a single vehicle crash in the Clarence Valley over the weekend.

Around 9:30pm on Saturday, March 11, emergency services were called to Kangaroo Creek Road, Coutts Crossing, about 30km south of Grafton, following reports a twin cab utility had left the roadway and struck a tree.

The driver, a 43-year-old man, and two passengers, a 14-year-old boy and an 11-year-old girl, tragically passed away at the scene.

Officers from the Coffs/Clarence Police District established a crime scene and commenced an investigation into the circumstances surrounding the incident.

A report will be prepared for the information of the coroner.

As inquiries continue, anyone with dashcam footage or further information regarding the incident is urged to contact CrimeStoppers on 1800 333 000.